Mood over time
How did participants rate their mood after 60 and 120 minutes? Explore the published measurements and their range.
Your pick-me-up to go.
Add liquid guayusa extract to your drink with LIMITLESS Drops, without brewing tea. Stir one full pipette per serving into your drink and follow the dosage instructions. The pipette bottle makes preparation easy on the go, too.
Choose your option & buy„Ich persönlich bevorzuge das Extrakt Pulver aber was die Zubereitung für unterwegs angeht sind die Drops im Vorteil“
Personal customer experience · Judge.me · Original excerpt · Original in German
Guayusa extractWith dropperWater-solubleMixes with hot or cold drinksLIMITLESS Drops at a glance
| Ingredients | Guayusa, water, alcohol (20%) |
|---|---|
| Origin | Guayusa leaves from Ecuador |
| Flavour | Mild and slightly sweet |
| Preparation | 1 ml per serving · mix into cold or warm drinks |
| Format | 50 ml · liquid Guayusa extract |
| Cost per serving · example | €0.90 EUR |
50 ml ÷ 1 ml = 50 servings. This is an example serving size; how much you use depends on your preparation.
Liquid guayusa extract
LIMITLESS Drops
Our Guayusa extract is a unique concentrate made 100% from Guayusa and is almost 100% water-soluble.
The flavour is very pleasant, slightly sweet, like a delicious Guayusa tea. Compared with our LIMITLESS Powder, the Drops taste even better because they are a full-spectrum extract that we have also developed with flavour in mind.
With 4–5 % caffeine and its full flavour profile, the Drops are the perfect addition for days when there’s no time to prepare tea.
Health-related properties
Effects of guayusa
Natural caffeine. Find your focus.
LIMITLESS Drops brings caffeine-containing Guayusa leaves into your everyday routine as a liquid extract. Caffeine blocks adenosine receptors and can therefore reduce tiredness while supporting alertness and attention. Mix the extract into your favourite drink – no need to brew a pot of tea first.
More than a single ingredient
Alongside caffeine, Guayusa contains antioxidant plant compounds, especially chlorogenic acids. This plant profile is what makes Guayusa extracts interesting to researchers. L-theanine is often discussed in connection with caffeine; however, the extract studies below examine each complete product and do not isolate an effect of L-theanine.
Your serving makes a difference
Use the dropper to measure LIMITLESS Drops for your drink. The liquid form is convenient to mix; it is not automatically faster-acting or longer-lasting than any other caffeine source. Follow the dosage instructions on your pack and count any other caffeinated drinks too.
Want to explore further? Our blog about L-theanine and caffeine and the Guayusa Wiki: Antioxidants offer background on the ingredients and research.
In three steps
Preparation
- 1. Prepare your drink
Prepare 400 ml of cold or warm water.
- 2. Measure
Add 1 ml of LIMITLESS Drops using the pipette.
- 3. Stir & enjoy
Stir well. Your drink is ready to enjoy.
1 ml is enough for one 400 ml glass.
Guayusa extract can be dissolved in cold or warm water. It is also suitable for shakes, smoothies and baking, for example energy bars with Macambo and cacao nibs, or as drops directly on the tongue.
There are many ways to use it.
Research made accessible
Research findings
Attention & focus
The research looks at both self-reported focus and computer-based tasks. These offer different perspectives on mental performance.
Working memory
The N-back test measured speed and accuracy when processing information.
Faster responses
The Go/No-go test shows how quickly participants respond to a signal and how reliably they withhold responses to other signals.
Gaming & restlessness
A direct comparison with synthetic caffeine and a placebo tracks the results over four hours – along with the limits of what they can tell us.
Guayusa compared
Another study looks at the adrenaline response to the same amount of caffeine from different sources.
Mood scale · 60 and 120 minutes
Mood improvement over time
After taking the Guayusa extract used in the study, participants rated their mood more positively than before taking it. Explore the changes after 60 and 120 minutes and select the time points for more details.
Mood improvement · Change on the mood scale (cm)
Time after intake
Guayusa extractBaseline (reference, not placebo)
0 = baseline. Dashed lines connect the reported changes; intermediate times were not measured here.
Explore the data points with your mouse, touch or Tab key.
Guayusa extract · 120 minutes: 0.67 cm · 0.14 to 1.2 (95% CI) · p 0.010
Points = reported change · Fine lines = 95% confidence interval
+0.30 cm
After one hour
On average, mood was rated more positively than before intake.
+0.67 cm
After two hours
The rating was still above baseline after 120 minutes.
What was measured?
Participants rated their mood on a visual analogue scale (VAS). The comparison is with their own baseline.
40 adults · Randomised, double-blind crossover study · 650 mg of the guayusa extract studied · Comparison within the extract condition, not against placebo.
La Monica et al. (2023), section 3.4 ↗Measurements and study context
The publication reports measurements before intake and after 60 and 120 minutes. Positive values indicate a better self-reported mood. Points show mean differences; fine lines show their 95% confidence intervals.
| Study condition | Time point | Measurement | Variability / interval |
|---|---|---|---|
| Guayusa extract | 60 minutes | 0.3 cm | 0.02 to 0.57 (95% CI) · p 0.036 |
| Guayusa extract | 120 minutes | 0.67 cm | 0.14 to 1.2 (95% CI) · p 0.010 |
The studies investigated the guayusa extracts specified in each case. The original findings are shown here; LIMITLESS Powder and Drops were not tested as finished GUYA products in these studies.
Working memory · N-back test
Improved reaction time
After 120 minutes, participants needed an average of 34.5 milliseconds less per point on the N-back test than at the start. Select the measurement to see the corresponding interval.
Reaction time in the N-back test · Change from baseline (ms)
Time after intake
Guayusa extractBaseline (reference, not placebo)
Downwards = less time per point. The dashed connection shows the difference from baseline, not a measured trajectory between time points.
Explore the data points with your mouse, touch or Tab key.
Guayusa extract · 120 minutes: −34.5 ms · −51.4 to −17.6 (95% CI) · p < 0.001
Points = reported change · Fine lines = 95% confidence interval
34.5 ms
Less time per point
This was the mean difference from the beginning of the N-back test.
120 min
After two hours
The displayed difference was measured at this time point.
The test behind the result
The N-back test assesses working memory and responses together. It compares the time needed per point scored.
40 adults · 650 mg of the guayusa extract studied · N-back: time per point scored · Comparison after 120 minutes with the same participants’ baseline.
La Monica et al. (2023), section 3.3 ↗Measurements and study context
34.5 ms less time per point in the working-memory test. This is not a general improvement in every type of reaction time. The chart shows the published difference and its 95% confidence interval.
| Study condition | Time point | Measurement | Variability / interval |
|---|---|---|---|
| Guayusa extract | 120 minutes | −34.5 ms | −51.4 to −17.6 (95% CI) · p < 0.001 |
The studies investigated the guayusa extracts specified in each case. The original findings are shown here; LIMITLESS Powder and Drops were not tested as finished GUYA products in these studies.
Go/No-go test, not overall decision quality
Responding faster to signals
Fast reactions and accurate reactions are two different things. This chart shows the time saved on Go signals after 60 and 120 minutes.
Faster responses to Go signals · Time saved (ms)
Time after intake
Guayusa extractBaseline (reference, not placebo)
Upwards = more time saved. Dashed lines connect the reported changes from the participants’ own baseline.
Explore the data points with your mouse, touch or Tab key.
Guayusa extract · 120 minutes: 14.6 ms · 4.21 to 24.9 (95% CI) · p 0.004
Points = reported change · Fine lines = 95% confidence interval
10.6 ms
After one hour
Mean reaction time to Go signals decreased by this amount.
14.6 ms
After two hours
The time saved compared with baseline was greater after 120 minutes.
Speed and accuracy
The chart shows response speed. No-go accuracy fell after 120 minutes compared with 60 minutes — both aspects are part of the result.
40 adults · 650 mg of the guayusa extract studied · Go/No-go test · Comparison within the extract condition, not against placebo.
La Monica et al. (2023), section 3.1 ↗Measurements and study context
The study measured reaction time to Go signals, not the quality of everyday decisions. Go responses became faster; however, No-go accuracy fell after 120 minutes compared with 60 minutes. Both speed and accuracy are part of the findings.
| Study condition | Time point | Measurement | Variability / interval |
|---|---|---|---|
| Guayusa extract | 60 minutes | 10.6 ms | 1.8 to 19.3 (95% CI) · p 0.015 |
| Guayusa extract | 120 minutes | 14.6 ms | 4.21 to 24.9 (95% CI) · p 0.004 |
The studies investigated the guayusa extracts specified in each case. The original findings are shown here; LIMITLESS Powder and Drops were not tested as finished GUYA products in these studies.
Guayusa extract, caffeine and placebo
Jitteriness compared in the study
With Guayusa extract, the average rating of restlessness remained unchanged after one hour. Compare the full pattern over time rather than just one selected percentage.
Jitteriness / inner restlessness · Self-rating from 0 to 100
Time after intake
Lower scores = less subjective restlessness. The lines connect the five measured time points.
Explore the data points with your mouse, touch or Tab key.
Guayusa extract · 1 hour: 30 /100 · ± 30 (SD)
Points = means · Selected point: ± standard deviation (SD)
30 → 30
Guayusa after one hour
The mean remained unchanged from baseline.
26 → 35
Caffeine after one hour
With synthetic caffeine, the mean rating initially increased.
Putting the comparison in context
The difference between guayusa and synthetic caffeine was not statistically significant. Subjective restlessness was measured.
49 active gamers (47 men, 2 women) · Crossover study · Guayusa extract and synthetic caffeine each providing 270 mg caffeine · 4 hours of gaming.
Bloomer et al. (2022), table 3 ↗Measurements and study context
After one hour, the guayusa mean remained at 30; with synthetic caffeine, it rose from 26 to 35. The difference between guayusa and caffeine was not statistically significant. These scores describe subjective restlessness, not objectively measured hand movements. Lines connect measured time points only; variability (± SD) is shown in the data table and when selecting a point.
| Study condition | Time point | Measurement | Variability / interval |
|---|---|---|---|
| Guayusa extract | 0 hours | 30 /100 | ± 29 (SD) |
| Guayusa extract | 1 hour | 30 /100 | ± 30 (SD) |
| Guayusa extract | 2 hours | 29 /100 | ± 28 (SD) |
| Guayusa extract | 3 hours | 23 /100 | ± 23 (SD) |
| Guayusa extract | 4 hours | 26 /100 | ± 24 (SD) |
| Synthetic caffeine | 0 hours | 26 /100 | ± 27 (SD) |
| Synthetic caffeine | 1 hour | 35 /100 | ± 28 (SD) |
| Synthetic caffeine | 2 hours | 27 /100 | ± 25 (SD) |
| Synthetic caffeine | 3 hours | 30 /100 | ± 28 (SD) |
| Synthetic caffeine | 4 hours | 28 /100 | ± 25 (SD) |
| Placebo | 0 hours | 23 /100 | ± 25 (SD) |
| Placebo | 1 hour | 24 /100 | ± 28 (SD) |
| Placebo | 2 hours | 25 /100 | ± 25 (SD) |
| Placebo | 3 hours | 25 /100 | ± 25 (SD) |
| Placebo | 4 hours | 20 /100 | ± 23 (SD) |
The studies investigated the guayusa extracts specified in each case. The original findings are shown here; LIMITLESS Powder and Drops were not tested as finished GUYA products in these studies.
Equal caffeine doses · Epinephrine response
Guayusa extract vs. synthetic caffeine
Caffeine is the same molecule; what accompanies it in the plant differs. Among other things, a small crossover study compared the adrenaline response to the same amount of caffeine.
Guayusa extract vs. synthetic caffeine · Urinary epinephrine (µg/gCr)
Time after intake
The comparison covers baseline and 60 minutes. The lines connect these two measurement points, not a continuously measured trajectory.
Explore the data points with your mouse, touch or Tab key.
Guayusa leaf extract · 60 minutes: 5.49 µg/gCr · ± 2.68 (SD)
Points = means · Selected point: ± standard deviation (SD)
200 mg
The same caffeine dose
Both conditions provided the same amount of caffeine — from guayusa leaf extract or a synthetic source.
4.99 → 5.49
Guayusa leaf extract
Mean epinephrine levels before intake and after 60 minutes (µg/gCr).
4.35 → 7.13
Synthetic caffeine
The mean increase was greater here. Difference between changes: p = 0.040.
12 healthy adult men · Double-blind crossover study · 200 mg caffeine from guayusa leaf extract or synthetic caffeine in each condition.
Krieger et al. (2016), table 5 ↗Measurements and study context
The rise in epinephrine was smaller with the guayusa extract studied (difference between changes: p = 0.040). Urinary epinephrine was measured, not focus, mood or an energy crash. Points show means; the selected point shows ± standard deviation. SD is not a confidence interval.
| Study condition | Time point | Measurement | Variability / interval |
|---|---|---|---|
| Guayusa leaf extract | Before intake | 4.99 µg/gCr | ± 3.24 (SD) |
| Guayusa leaf extract | 60 minutes | 5.49 µg/gCr | ± 2.68 (SD) |
| Synthetic caffeine | Before intake | 4.35 µg/gCr | ± 3.55 (SD) |
| Synthetic caffeine | 60 minutes | 7.13 µg/gCr | ± 4.02 (SD) |
The studies investigated the guayusa extracts specified in each case. The original findings are shown here; LIMITLESS Powder and Drops were not tested as finished GUYA products in these studies.
Preparation and serving ideas
Does LIMITLESS Drops fit your day?
Guayusa in liquid form.
Liquid Guayusa extract for your drinks.
Measure with the pipette.
One serving is 1 ml.
Mix into hot or cold drinks.
Add the Drops to your drink and give it a brief stir.
The story behind your GUYA
Get to know LIMITLESS Drops
Discover LIMITLESS Drops in the video: learn about the ingredients, where they come from and ideas for your own GUYA ritual.
Our Limitless Drops are named after the remarkable biohacking pill from the film of the same name, "Limitless" (released in Germany as "Ohne Limit").
It is a highly concentrated, natural source of energy made from 100% Guayusa leaves. Perfect for intense, long-lasting energy without the typical side effects of coffee and energy drinks.
Our 100% Guayusa concentrate is unique on the market.
As the only full-spectrum extract obtained using ultrasound available on the European market, Limitless Drops can compete with any chemical caffeine booster. Few people know how important and effective antioxidants and other plant compounds are for an energy boost, focus and avoiding “brain fog”.
For research-based information about the effects of Guayusa, visit the Guayusa Wiki and the Detox-Tee Wiki.
Our Limitless Drops are water-soluble and can therefore be consumed in any form as an energiser. We recommend taking one full pipette per serving. One bottle is enough for 50 servings.
Mix Limitless Drops into smoothies, protein-shakes, porridge, tea, hot or cold water, juice, or make your own energy bars with nuts and rolled oats. You can also drop them directly onto your tongue.
The taste is mild, slightly sweet, entirely free of bitter compounds and every bit as good as original Guayusa PURE.
With us, you can be sure that we are more than just ingredient resellers. On our YouTube channel, you’ll find short documentaries and vlogs featuring our farmers in Ecuador. GUYA founder Sebastian gives you a transparent look at how we work together and how your Guayusa is produced.
In our YouTube videos
Scroll sideways to explore all videos.
GUAYUSA EXTRACT: why Dave Asprey loves this superfood!
Click to load the YouTube player. Watch on YouTube
What the film Limitless has in common with guayusa – One Limit
Click to load the YouTube player. Watch on YouTubeIn our blog articles
Limitless Powder vs. the competition: the ultimate comparison
Compare LIMITLESS Guayusa extract with Red Bull, coffee and other options for focus, energy and performance, including how energy crashes...
Read article
Guayusa extract: the caffeine paradox? Energy without jitters
Can guayusa provide 6+ hours of energy without jitters or a crash? Explore the caffeine paradox and the evidence behind...
Read article
Limitless Powder biohacking recipes: a guide to natural energy & focus
Discover more than 20 creative biohacking recipes with GUYA Limitless Powder, from energy smoothies to warm drinks, for naturally optimising...
Read articleTransparency & product overview
M
Praktisch für unterwegs und wie gewohnt ist Guayusa der beste natürliche Wachmacher für mich. Ich persönlich bevorzuge das Extrakt Pulver aber was die Zubereitung für unterwegs angeht sind die Drops im Vorteil
K
Die Limitless-Drops sind super einfach in der Anwendung und schmecken mir in allen kalten und warmen Flüssigkeiten sehr gut.
Das Guayusa Extrakt-Konzentrat ist perferkt, um auch unterwegs wach und konzentriert zu bleiben, egal ob im Kaffee oder in der Cola ist es einfach die allerbeste Lösung sich mit Guayusa bzw. Koffein zu versorgen. Geht definitiv auch mit den Urlaub.
Für mich ist das Konzentrat jeden Penny wert!
Einziger Wermutstropfen ist, es enthält 20% Alkohol, so dass es nicht für jeden geeignet ist.
A
Energy-Konzentrat als praktische Idee zum Mitnehmen für unterwegs.
Habe dieses Extrakt jetzt 3 Tage lang verwendet und in diversen Getränken eingenommen (Früchtetee, Softdrinks, Kakao). Wirkung gut spürbar, wie bei Guayusa gewohnt, Eigengeschmack aber etwas zu intensiv beim Mischen in anderen Getränken.
Für mich eine tolle Ergänzung im Sortiment von "Drinkguya".
Besonders interessant und vorteilhaft für mich, wenn ich unterwegs bin, z.B.: auf Urlaubs- oder Dienstreisen.
Dieses Produkt kann ich mit gutem Gewissen empfehlen!
