Mood over time
How did participants rate their mood after 60 and 120 minutes? Explore the published measurements and their range.
Stir LIMITLESS Powder into water, juice or a smoothie to mix your own caffeinated drink. This water-soluble guayusa extract is concentrated, unlike ground guayusa leaf. The included scoop holds about 0.25 g; use no more than 0.5 g per serving and follow the dosage instructions.
Choose your option & buy„Mir schmeckt es super ohne Zucker“
| Ingredients | 100% Guayusa extract |
|---|---|
| Origin | Guayusa leaves from Ecuador |
| Preparation | Dissolve 0.5 g in 400 ml of cold or warm water |
| Format | 30 g · water-soluble extract powder |
| Cost per serving · example | €0.83 EUR |
30 g ÷ 0.5 g = 60 servings. This is an example serving size; how much you use depends on your preparation.
Powdered guayusa extract
Our Guayusa extract is a unique concentrate made from 100% Guayusa and is almost 100% water-soluble.
Its flavour comes very close to original Guayusa tea. With 22% caffeine and 30% antioxidants, our Guayusa extract powder is the world’s strongest natural extract!


Health-related properties
LIMITLESS Powder brings caffeine-containing Guayusa leaves into your everyday routine as a concentrated powder. Caffeine blocks adenosine receptors and can therefore reduce tiredness while supporting alertness and attention. Mix the extract into your favourite drink – no need to brew a pot of tea first.
Alongside caffeine, Guayusa contains antioxidant plant compounds, especially chlorogenic acids. This plant profile is what makes Guayusa extracts interesting to researchers. L-theanine is often discussed in connection with caffeine; however, the extract studies below examine each complete product and do not isolate an effect of L-theanine.
LIMITLESS Powder is a concentrated extract, not the same as ground Guayusa leaves. Measure small portions carefully and follow the dosage instructions on your pack. Remember to count coffee, tea and other caffeine sources throughout the day.
Want to explore further? Our blog about L-theanine and caffeine and the Guayusa Wiki: Antioxidants offer background on the ingredients and research.


In three steps
Prepare 400 ml of cold or warm water.
Add 0.5 g of LIMITLESS Powder.
Stir well. Your drink is ready to enjoy.
0.5 g is enough for one 400 ml glass. We do not recommend more than 1.5 g per day.
Guayusa extract powder can be dissolved in cold or warm water. It is also suitable for shakes, smoothies and baking.
There are no limits to how you can use it.
Research made accessible
How did participants rate their mood after 60 and 120 minutes? Explore the published measurements and their range.
The research looks at both self-reported focus and computer-based tasks. These offer different perspectives on mental performance.
The N-back test measured speed and accuracy when processing information.
The Go/No-go test shows how quickly participants respond to a signal and how reliably they withhold responses to other signals.
A direct comparison with synthetic caffeine and a placebo tracks the results over four hours – along with the limits of what they can tell us.
Another study looks at the adrenaline response to the same amount of caffeine from different sources.
Mood scale · 60 and 120 minutes
After taking the Guayusa extract used in the study, participants rated their mood more positively than before taking it. Explore the changes after 60 and 120 minutes and select the time points for more details.
Mood improvement · Change on the mood scale (cm)
Time after intake
0 = baseline. Dashed lines connect the reported changes; intermediate times were not measured here.
Explore the data points with your mouse, touch or Tab key.
Guayusa extract · 120 minutes: 0.67 cm · 0.14 to 1.2 (95% CI) · p 0.010
Points = reported change · Fine lines = 95% confidence interval
On average, mood was rated more positively than before intake.
The rating was still above baseline after 120 minutes.
Participants rated their mood on a visual analogue scale (VAS). The comparison is with their own baseline.
40 adults · Randomised, double-blind crossover study · 650 mg of the guayusa extract studied · Comparison within the extract condition, not against placebo.
La Monica et al. (2023), section 3.4 ↗The publication reports measurements before intake and after 60 and 120 minutes. Positive values indicate a better self-reported mood. Points show mean differences; fine lines show their 95% confidence intervals.
| Study condition | Time point | Measurement | Variability / interval |
|---|---|---|---|
| Guayusa extract | 60 minutes | 0.3 cm | 0.02 to 0.57 (95% CI) · p 0.036 |
| Guayusa extract | 120 minutes | 0.67 cm | 0.14 to 1.2 (95% CI) · p 0.010 |
The studies investigated the guayusa extracts specified in each case. The original findings are shown here; LIMITLESS Powder and Drops were not tested as finished GUYA products in these studies.
Working memory · N-back test
After 120 minutes, participants needed an average of 34.5 milliseconds less per point on the N-back test than at the start. Select the measurement to see the corresponding interval.
Reaction time in the N-back test · Change from baseline (ms)
Time after intake
Downwards = less time per point. The dashed connection shows the difference from baseline, not a measured trajectory between time points.
Explore the data points with your mouse, touch or Tab key.
Guayusa extract · 120 minutes: −34.5 ms · −51.4 to −17.6 (95% CI) · p < 0.001
Points = reported change · Fine lines = 95% confidence interval
This was the mean difference from the beginning of the N-back test.
The displayed difference was measured at this time point.
The N-back test assesses working memory and responses together. It compares the time needed per point scored.
40 adults · 650 mg of the guayusa extract studied · N-back: time per point scored · Comparison after 120 minutes with the same participants’ baseline.
La Monica et al. (2023), section 3.3 ↗34.5 ms less time per point in the working-memory test. This is not a general improvement in every type of reaction time. The chart shows the published difference and its 95% confidence interval.
| Study condition | Time point | Measurement | Variability / interval |
|---|---|---|---|
| Guayusa extract | 120 minutes | −34.5 ms | −51.4 to −17.6 (95% CI) · p < 0.001 |
The studies investigated the guayusa extracts specified in each case. The original findings are shown here; LIMITLESS Powder and Drops were not tested as finished GUYA products in these studies.
Go/No-go test, not overall decision quality
Fast reactions and accurate reactions are two different things. This chart shows the time saved on Go signals after 60 and 120 minutes.
Faster responses to Go signals · Time saved (ms)
Time after intake
Upwards = more time saved. Dashed lines connect the reported changes from the participants’ own baseline.
Explore the data points with your mouse, touch or Tab key.
Guayusa extract · 120 minutes: 14.6 ms · 4.21 to 24.9 (95% CI) · p 0.004
Points = reported change · Fine lines = 95% confidence interval
Mean reaction time to Go signals decreased by this amount.
The time saved compared with baseline was greater after 120 minutes.
The chart shows response speed. No-go accuracy fell after 120 minutes compared with 60 minutes — both aspects are part of the result.
40 adults · 650 mg of the guayusa extract studied · Go/No-go test · Comparison within the extract condition, not against placebo.
La Monica et al. (2023), section 3.1 ↗The study measured reaction time to Go signals, not the quality of everyday decisions. Go responses became faster; however, No-go accuracy fell after 120 minutes compared with 60 minutes. Both speed and accuracy are part of the findings.
| Study condition | Time point | Measurement | Variability / interval |
|---|---|---|---|
| Guayusa extract | 60 minutes | 10.6 ms | 1.8 to 19.3 (95% CI) · p 0.015 |
| Guayusa extract | 120 minutes | 14.6 ms | 4.21 to 24.9 (95% CI) · p 0.004 |
The studies investigated the guayusa extracts specified in each case. The original findings are shown here; LIMITLESS Powder and Drops were not tested as finished GUYA products in these studies.
Guayusa extract, caffeine and placebo
With Guayusa extract, the average rating of restlessness remained unchanged after one hour. Compare the full pattern over time rather than just one selected percentage.
Jitteriness / inner restlessness · Self-rating from 0 to 100
Time after intake
Lower scores = less subjective restlessness. The lines connect the five measured time points.
Explore the data points with your mouse, touch or Tab key.
Guayusa extract · 1 hour: 30 /100 · ± 30 (SD)
Points = means · Selected point: ± standard deviation (SD)
The mean remained unchanged from baseline.
With synthetic caffeine, the mean rating initially increased.
The difference between guayusa and synthetic caffeine was not statistically significant. Subjective restlessness was measured.
49 active gamers (47 men, 2 women) · Crossover study · Guayusa extract and synthetic caffeine each providing 270 mg caffeine · 4 hours of gaming.
Bloomer et al. (2022), table 3 ↗After one hour, the guayusa mean remained at 30; with synthetic caffeine, it rose from 26 to 35. The difference between guayusa and caffeine was not statistically significant. These scores describe subjective restlessness, not objectively measured hand movements. Lines connect measured time points only; variability (± SD) is shown in the data table and when selecting a point.
| Study condition | Time point | Measurement | Variability / interval |
|---|---|---|---|
| Guayusa extract | 0 hours | 30 /100 | ± 29 (SD) |
| Guayusa extract | 1 hour | 30 /100 | ± 30 (SD) |
| Guayusa extract | 2 hours | 29 /100 | ± 28 (SD) |
| Guayusa extract | 3 hours | 23 /100 | ± 23 (SD) |
| Guayusa extract | 4 hours | 26 /100 | ± 24 (SD) |
| Synthetic caffeine | 0 hours | 26 /100 | ± 27 (SD) |
| Synthetic caffeine | 1 hour | 35 /100 | ± 28 (SD) |
| Synthetic caffeine | 2 hours | 27 /100 | ± 25 (SD) |
| Synthetic caffeine | 3 hours | 30 /100 | ± 28 (SD) |
| Synthetic caffeine | 4 hours | 28 /100 | ± 25 (SD) |
| Placebo | 0 hours | 23 /100 | ± 25 (SD) |
| Placebo | 1 hour | 24 /100 | ± 28 (SD) |
| Placebo | 2 hours | 25 /100 | ± 25 (SD) |
| Placebo | 3 hours | 25 /100 | ± 25 (SD) |
| Placebo | 4 hours | 20 /100 | ± 23 (SD) |
The studies investigated the guayusa extracts specified in each case. The original findings are shown here; LIMITLESS Powder and Drops were not tested as finished GUYA products in these studies.
Equal caffeine doses · Epinephrine response
Caffeine is the same molecule; what accompanies it in the plant differs. Among other things, a small crossover study compared the adrenaline response to the same amount of caffeine.
Guayusa extract vs. synthetic caffeine · Urinary epinephrine (µg/gCr)
Time after intake
The comparison covers baseline and 60 minutes. The lines connect these two measurement points, not a continuously measured trajectory.
Explore the data points with your mouse, touch or Tab key.
Guayusa leaf extract · 60 minutes: 5.49 µg/gCr · ± 2.68 (SD)
Points = means · Selected point: ± standard deviation (SD)
Both conditions provided the same amount of caffeine — from guayusa leaf extract or a synthetic source.
Mean epinephrine levels before intake and after 60 minutes (µg/gCr).
The mean increase was greater here. Difference between changes: p = 0.040.
12 healthy adult men · Double-blind crossover study · 200 mg caffeine from guayusa leaf extract or synthetic caffeine in each condition.
Krieger et al. (2016), table 5 ↗The rise in epinephrine was smaller with the guayusa extract studied (difference between changes: p = 0.040). Urinary epinephrine was measured, not focus, mood or an energy crash. Points show means; the selected point shows ± standard deviation. SD is not a confidence interval.
| Study condition | Time point | Measurement | Variability / interval |
|---|---|---|---|
| Guayusa leaf extract | Before intake | 4.99 µg/gCr | ± 3.24 (SD) |
| Guayusa leaf extract | 60 minutes | 5.49 µg/gCr | ± 2.68 (SD) |
| Synthetic caffeine | Before intake | 4.35 µg/gCr | ± 3.55 (SD) |
| Synthetic caffeine | 60 minutes | 7.13 µg/gCr | ± 4.02 (SD) |
The studies investigated the guayusa extracts specified in each case. The original findings are shown here; LIMITLESS Powder and Drops were not tested as finished GUYA products in these studies.
Preparation and serving ideas
LIMITLESS Powder is concentrated Guayusa extract for mixing.
Dissolve 0.5 g in 400 ml of cold or warm water.
Discover more ways to prepare your extract.
The story behind your GUYA
Our LIMITLESS Powder is named after the remarkable biohacking pill from the film of the same name, "Limitless" (released in German as "Ohne Limit").
It is a highly concentrated natural energy source made from 100% Guayusa leaves, with no additives, drying agents or anti-caking agents. It is intended for intense, long-lasting energy without the typical side effects of coffee and energy drinks.
Our 100% Guayusa concentrate is unique on the market.
With 22% Guayusa caffeine and 30% valuable antioxidants such as lutein, our natural powdered extract competes with chemical caffeine boosters. Few people know how important and effective antioxidants are in relation to an energy boost, focus and avoiding “brain fog”.
Our LIMITLESS Powder is 99.89% water-soluble, so it can be consumed as an energiser in many different ways. We recommend taking no more than 0.5 g per serving. One pack is therefore enough for 60 servings, or about 2 months.
For research-based information about Guayusa, visit the Guayusa Wiki and the Detox-Tee Wiki.
Mix LIMITLESS Powder into smoothies, protein shakes, porridge, tea, hot or cold water, or juice; you can also make your own energy bars with nuts and oats.
Its flavour is mild and very close to the original Guayusa PURE.
You can be sure we are more than just resellers of ingredients. On our YouTube channel you’ll find short documentaries and vlogs featuring our farmers in Ecuador. GUYA founder Sebastian shows you transparently how we work together and how your Guayusa is produced.
P.S.: A measuring spoon for approx. 0.25 g is included!
NOTE: The best-before date of this product is 30.01.27. A best-before date is not a use-by or expiry date: it describes the period for which the full quality of an unopened, correctly stored pack must be guaranteed by law. The light-, moisture- and odour-protecting packaging supports the preservation of quality. That is why our products keep the same quality for at least two years beyond the best-before date. In addition, our extract is tested for a minimum shelf life of five years from production — in Germany, however, we may initially only state two years. Selling beyond that is legally permitted as long as the quality is guaranteed.
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